Second Installment of SLC Systematic Review Webinar Series - November 27

The Scientific Liaison Coalition, of which the Teratology Society is a member, will host the second installment of this webinar series on November 27. Registration via the link below is required. The live webinar is open to members of SLC member societies, including the Teratology Society. A recording of the webinar will be placed in the Educational Webinars File Library on BDR Connection soon after the live webinar takes place.

Practical Application of SR in Preclinical Research and Risk-based Assessments
Tuesday, November 27, 11:00 AM–12:30 PM ET USA

Chaired by Katya Tsaioun, PhD, Director, Evidence-Based Toxicology Collaboration, Johns Hopkins Center for Alternatives to Animal Testing, Bloomberg School of Public Health, Baltimore. Dr. Tsaioun will introduce the History and Main Principles of Systematic Review. Kim Wever, PhD, Researcher, Radboud University Medical Center, The Netherlands, will present on Tail-ored: Applying the Concept and Methodology of SR and Meta-analysis to Preclinical Animal Studies. SR help clinicians keep abreast of the medical literature by summarizing large bodies of evidence and helping to explain differences among studies on the same question. Used to inform medical decision-making, plan future research agendas, and establish policy, SR methods are ready to be adopted in risk assessment. Dr. Wever will present several case studies on application of the principles of SR to the evaluation of preclinical animal studies conducted by SYRCLE and others. Challenges in conducing SRs in preclinical research will be addressed. Recent solutions to these challenges such as recently opened pre-registration of preclinical protocols, internal validity (risk of bias) tools, external validity (generalizability of results) will be presented. Daniele Wikoff, PhD, ToxStrategies, will present on Practical Examples of the Integration of Systematic Review to Support Development of Health-based Toxicity Values in Chemical Risk Assessments. This presentation brings together the different applications of SR in the context of quantitative risk-based assessments, differentiating how the rigor and conduct of the approach must accommodate concepts beyond identification and characterization of hazard. An overview of common challenges with respect to procedures and tools utilized in the conduct of quantitative evidence-based assessments will be provided. This will include an introduction to challenges associated with the integration of multi-endpoint and multi-stream evidence bases, as well as integration of internal and external validity as they relate to selection of candidate datasets and development of toxicity values (and how such approaches may be refined relative to application of these concepts in qualitative vs. quantitative assessments). Register

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