High-Throughput Toxicity Testing Data Analysis - Posted May 5, 2015

High-Throughput Toxicity Testing Data Analysis


Brief description of research project: The NCCT provides scientific leadership, understanding and tools related to the application of mathematical and computer models to technologies derived from computational chemistry, molecular biology and systems biology, with the goal of improving the Agency’s understanding of chemical toxicity and exposure as it relates to chemical prioritization and risk assessment. The research participant will become part of a dynamic, interdisciplinary team to apply systems-based approaches toward advancing scientific principles and strategies for alternatives assessment. With guidance from a mentor, the participant will have the opportunity to analyze data from high-throughput assays for use in developing models for bioactivity and toxicity of environmental contaminants. Areas of research include: high-throughput cell-based or cell-free assays, in vitro models of cell signaling or functional cellular phenotypes, nuclear receptor signaling, and stress pathways. The participant will have latitude in exercising independent initiative and judgment in the research commensurate with the level of training.

Geographical location of position: Research Triangle Park, NC

High priority research areas: Computational Toxicology

Scientific project area: Chemical Safety for Sustainability (CSS) National Research Program

Educational requirements: PhD in cell biology, toxicology, pharmacology or a related discipline.

Specialized training and/or experience preferred: Candidates should have experience in analyzing and interpreting in vitro and model organism assays targeting toxicity pathways and potential molecular initiating events. Ability to work with large data sets including data visualization techniques is desired. The ability to use chemoinformatics tools to link chemical structure to biological activity is also preferred. 

Projected duration of appointment: 3 years

Paid relocation to EPA work location: Yes

Application Period Open Date: May 04, 2015

Application Period Close Date: Jun 08, 2015

Scientific contact/Principal Investigator(s)*: Keith Houck, houck.keith@epa.gov, 919-541-5519




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