Teratology Society Takes Part in First of Three ‘Scientific Rigor’ FASEB Roundtables

Teratology Society Takes Part in First of Three

‘Scientific Rigor’ FASEB Roundtables

WASHINGTON D.C. – The first in a series of roundtable discussions addressing new requirements for researchers submitting grant applications kicked off late last month with Teratology Society representatives, Palma Ann Marone, PhD, ERT, FACN, and Belen Tornesi, DVM, MS, taking an active part.

In January of next year, the new National Institutes of Health (NIH) policy to address rigor and transparency in grant applications goes into effect. According to the Federation of American Societies for Experimental Biology (FASEB), new grant proposals involving mouse models must consider the strength of the body of work that the proposed work will build upon; design experiments that are unbiased and rigorous; consider sex and other biological variables such as age, weight, and underlying health conditions in vertebrate animals focusing on the appropriate and discriminate use of animals, always keeping in mind that best practices for animals must be in accordance with their ethical use and welfare.

Marone, who recently became the Society’s representative on FASEB’s Science Policy Committee, said FASEB’s goal of these roundtables is to develop consensus principles that guide scientists in validating the resources used in research. Researchers could then reference these principles in their grant applications to fulfill new NIH requirements.

 “The first roundtable on the rigor and reproducibility of research using mouse models focused on the methods and guidelines under which mouse models are used and the resources available to mitigate the variabilities inherent in their use, particularly those of housing and husbandry, terminology, training and handling, species and strain differences, and limitations of the model,” reported Marone, who is also an adjunct professor at the Virginia Commonwealth University School of Medicine.

Learn more about the key issues discussed during the first roundtable.

The goal of the second roundtable, scheduled for later this month, will focus on developing a consensus for validating antibodies and the various levels of quality controls, as well as the standards governing their use.



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