Two Special Issues of Neurotoxicology and Teratology Now Available

Two special issues of Neurotoxicology and Teratology, the journal of our sister society Developmental Neurotoxicology Society (DNTS) are now available.

The first special issue, Neurotoxicology and Teratology Volume 52 Part A examines the strengths and limitations of the use of cognitive tests in developmental neurotoxicity testing.  This special issue features papers authored by Teratology Society members Susan L. Makris and Charles V. Vorhees and follows the Regulatory Neurodevelopmental Testing: New Guiding Principles for Harmonization of Data Collection and Analysis Workshop held at the annual meetings of the Teratology Society and DNTS last summer in Montreal.

Assessments of cognitive function have been recommended for guideline developmental neurotoxicity studies of pesticides and environmental chemicals for more than two decades. However, the results of these tests have rarely been used as points of departure for regulatory decisions. Some have even suggested eliminating these tests from developmental neurotoxicity testing protocols.

The articles in this special issue discuss:

  • The regulatory context in which developmental neurotoxicity testing is carried out;

  • Evaluations of the efficacy of these tests for regulatory decision-making;

  • Descriptions of the state of the science of cognitive testing for regulatory purposes;

  • Discussion of possible reasons for the infrequent use of these endpoints in regulatory decisions; and

  • Proposals to enhance the sensitivity and practical application of these tests in this testing environment.

The editors of Neurotoxicology and Teratology believe that discussion of these issues will provide guidance for improving developmental neurotoxicity testing in the future.

DNTS invites comments on the utility of current cognitive test methods and ways that these methods for assessing cognitive function in guideline-based developmental neurotoxicity studies might be improved or enhanced, in order to maximize the future value of cognitive data in a regulatory context. Submit comments to in the form of correspondence to the editor at the journal’s website no later than March 15, 2016. The journal’s Section Editor for Special Issues, Dr. Jerrold Meyer, will handle submissions on this topic.

The second special issue, Neurotoxicology and Teratology Volume 52 Part B investigates the neurotoxicity of past, present and future flame retardants and describes the changing landscape of flame retardant chemicals and provides an up-to-date evaluation of the effects and relative toxicity of many of the alternatives.

Exposure to flame retardants, particularly halogenated ones, is increasingly common today. Recent work has revealed a troubling degree of toxicity among some of these chemicals, prompting deployment of a variety of alternatives.

The articles in this special issue discuss:

  • Experimental studies in five animal species and two epidemiological studies in humans;

  • Experimental studies of polybrominated diphenyl ethers and newer organophosphorous alternatives; and

  • An extensive review that organizes the literature and provides qualitative expert judgment about the likely public health impact of these chemicals and specific research that is needed to address existing data gaps for each of them.

The editors of Neurotoxicology and Teratology believe that this special issue provides the field with an invaluable resource to propel research on these important chemicals at a critical time in their history. Research toxicologists, regulators, risk managers, and the industry itself are encouraged to examine this work and apply it to the benefit of public health.




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