State of the Art in the Cramer Classification Scheme and Threshold of Toxicological Concern - Mar 29

SOT FDA Banner


The Society of Toxicology is pleased to announce the next colloquium presented in conjunction with the FDA Center for Food Safety and Applied Nutrition (CFSAN). “State of the Art in the Cramer Classification Scheme and Threshold of Toxicological Concern” will be March 29, 2016, from 8:30 AM-1:00 PM in Wiley Auditorium on the CFSAN campus in College Park, Maryland. The objectives of this colloquium include a review of the evolution of the Cramer Decision Tree and TTC approach, presentation of possible revisions to the original Cramer Decision Tree and its impact on TTC levels for other routes of exposure, and a discussion of the possible expansion of the Cramer Decision Tree or other computational approaches to more diverse chemicals, multiple structural classes, and the chemical specificity of questions.  

This scientific training is high quality, cutting-edge, future-oriented toxicological science to provide a well-grounded, foundation to inform the work of FDA employees and depth of knowledge for others. The focus is a discussion of emerging toxicology methods and the sessions are not a public forum for discussion of toxicology regulatory issues.

We welcome participation from our colleagues who are members of Teratology Society. 

 The colloquium is open to the public to attend in person or via webcast. 


Speakers include:

  • Threshold of Toxicological Concern Approach in Regulatory Decision-Making: The Past, Present, and Future, Grace Tier, US EPA, Research Triangle Park, NC
  • Advancements in Food Ingredient Safety Prioritization: An Expanded Cramer Decision Tree Schema, Timothy Adams, US FDA, College Park, MD
  • In Silico Methods for Threshold of Toxicological Concern Assessment, Andrew Worth, European Commission, Joint Research Centre, Ispra, Italy
  • Quantitative Prediction of Continuous Toxicity Values using Chemical Structure Information, Jessica Wignall, ICF International,  Arlington, VA

These talks will be followed with a roundtable discussion moderated by Ivan Rusyn, Texas A&M and Kristi Jacobs, US FDA. Questions from the audience on-site and participating in the webcast are encouraged. 

In addition, the recording and materials from the previous sessions as well as additional information can be accessed at the Colloquia website. Questions? Contact SOT at, 703.438.3115 Ext 1602.

Recent Stories
NICHD Decoding Maternal Morbidity Data Challenge Webinar on July 22

BDRP Members in the News!

Contribute to the BDRP Science Committee Running List of Hot and Cutting Edge Science Topics